FAF1 (Fas-associated protein factor 1) specifically interacts with the cytoplasmic domain of wild type，but not mutated，Fas in both yeast and mammalian cells. When transiently expressed in T cells，FAF1 potentiates Fas-induced apoptosis. In contrast to TRADD，FADD，and RIP，FAF1 lacks a DDH (Death domain homologous region) and cannot induce apoptosis independent of Fas activation.
应用类型
Western blot, Immunoprecipitation, Immunohistochemistry
免疫原
Synthetic peptide corresponding to residues surrounding amino acid 640 of human FAF1
