Members of Oct family of transcription factors specifically interact with Octamer motif ATGCAAAT，a regulatory element important for tissue- and cell-specific transcription as well as for transcription of a number of housekeeping genes. All of the members of the Oct family contain two highly conserved domains which are separated by 14-26 variable amino acids. These include the POU homeodomain and the POU-specific domain. Both are required for DNA binding and are involved in protein-protein interactions. Evidences indicate that regulation of Oct family transcription factors occurs at the level of phosphorylation.
应用类型
Western blot, Immunohistochemistry
免疫原
Synthetic peptide surrounding amino acid 727 of human Oct-1
