Receptor interacting protein including RIP and RIP2/RICK mediate apoptosis induced by TNFR1 and Fas，two prototype members in the death receptor family. A novel member in the RIP kinase family was recently identified and designated RIP3. RIP3 contains N-terminal kinase domain but，unlike RIP or RIP2，lacks the c-terminal death or CARD domain. RIP3 binds to RIP and TNFR1，and mediates TNF-R1 mediated apoptosis，and attenuates RIP and TNFR1 induced NFkB activation. Overexpression of RIP3 induces apoptosis and NFkB activation.
应用类型
Western blot, Immunohistochemistry
免疫原
Synthetic peptide corresponding to residues surrounding amino acid 476 of mouse RIP3
