MKK3 is a protein kinase that phosphorylates the p38 MAPK. Phosphorylation by MKK3 occurs on threonine and tyrosine residues and increases the activity of p38 to stimulate transcription factors ATF2 and Elk-1. MKK3，together with MKK6，serves as upstream regulators of p38 MAPK activation. A structural variant，MKK3b，has been identified that contains 29 more amino acids at its N-terminus.
应用类型
Western blot analysis （0.5-4 ug/ml） and immunoprecipitation. However， the optimal conditions should be determined individually.
免疫原
E. coli-expressed full-length human MKK3
来源宿主
兔
反应性
经检测验证，可与人种属来源的MKK3蛋白发生免疫反应.
保存建议
提供的MKK3抗体产品为100 ug 无色溶液，其浓度为0.2 mg/ml，溶解于包含有50%甘油， 1% BSA， 0.02%硫柳汞的PBS （pH 7.2）缓冲液中.请将该MKK3抗体产品置于-20 ℃冷冻保存，建议分装使用以避免反复冻融.
