Silent information regulator (Sir2)-like family deacetylases (also known as sirtuins) are highly conserved proteins and have important roles in the regulation of metabolism，inflammation，cellular survival growth and differentiation. Sirtuins，including SIRT1-7，are human homologs of yeast Sir2p. Sirtuins are NAD-dependent protein ADP-ribosyl transferase which catalyzes the transfer of ADP-ribosyl groups onto target proteins，including mitochondrial GLUD1. SIRT4 localizes to mitochondria，inhibits glutamate dehydrogenase (GLUD1)，and may involve in the regulation of insulin secretion.
应用类型
Western blot
免疫原
Synthetic peptide surrounding amino acid 72 of rat SIRT4
