TrkA，the high affinity Nerve Growth Factor (NGF) receptor，autophosphorylates on tyrosine to activate multiple effectors. Phosphorylation at Tyr490 is required for Shc association and activation of the Ras-MAP kinase cascade. Residues Tyr674/675 lie within the catalytic domain，and phosphorylation at these sites reflects Trk kinase activity.
应用类型
Western blot, Immunoprecipitation, Immunohistochemistry
免疫原
Synthetic peptide surrounding amino acid 494 of human TrkA
