Jagged belongs to the DeltaSerrateLag2 （DSL） family of ligands that activate LIN12/Notch proteins. Ligands for Notch include Jagged1，Jagged2 and Delta. Jagged 1is involved in mammalian cardiovascular development and in cell-fate decisions during hematopoiesis. Mutation in Jagged1 is associated with an autosomal dominant disorder known as Alagille syndrome and Familial Tetralogy of Fallot a form of complex congenital heart disease.
应用类型
Western Blot analysis （1-4 ug/ml）. However， the optimal concentrations should be determined individually. Blocking peptide （Cat.# 3101BP-50） is available separately.
免疫原
Synthetic peptide surrounding amino acid 114 of rat Jagged 1
来源宿主
兔
反应性
经检测验证，可与人、小鼠种属来源的Jagged 1蛋白发生免疫反应
保存建议
提供的100 ug Jagged 1抗体产品为无色溶液其浓度为0.5 mg/ml溶解于包含有30%甘油， 0.5% BSA， 5 mM EDTA和0.01%硫柳汞的PBS （pH 7.2）缓冲液中.请将该Jagged 1抗体产品置于-20 °C冷冻保存，建议分装使用以避免反复冻融.
