Granzyme B is a 27 kDa serine protease stored in granules of activated cytotoxic T cells and NK cells. Upon target cell contact，granzyme B is directionally exocytosed and assisted by perforin，enters the target cell. With its unique substrate specificity (granzyme B cleaves after Asp)，granzyme B processes and activates various pro-caspases thereby inducing apoptosis in the target cell.
应用类型
Western blot
免疫原
Synthetic peptide corresponding to residues surrounding amino acid 221 of human Granzyme B
