Fas-associating death domain containing protein (FADD)，also known as mediator of receptor induced toxicity (MORT1)，is a 23 kDa cytosolic protein with an apparent molecular weight of 28 kDa on SDS-PAGE. The protein is involved in both Fas and TNF-R induced cell death pathway. FADD specifically binds to Fas to initiate the apoptotic signalling cascade. Overexpression of FADD induces apoptosis.
应用类型
Western blot, Immunoprecipitation
免疫原
Synthetic peptide surrounding amino acid 128 of human FADD
