- 中文名称
Myeloperoxidase (MPO) Inhibitor, Screening BioAssay Kit (Fluorometric)
- 英文名字
- Myeloperoxidase (MPO) Inhibitor, Screening BioAssay Kit (Fluorometric)
- 供应商
- USBiological
- 产品货号
- 301246
- 产品报价
- ￥1/200Tests
- 产品说明书
- 点击查看
- 购买方式
- 银行转账、电汇、支票、现金，在线支付宝及网银支付，或直接与我们电话联系400-6800-868
- 产品新闻
- 背景资料
- USBiological品牌是全球有名的抗原抗体和生化试剂供应商，生产世界上种类最多的抗体，用于Western Blot、免疫沉淀、免疫荧光、免疫组化和流式细胞术等多种检测方法。武汉艾美捷科技作为USBiological品牌中国区域总代理，是行业中少有的致力于服务客户，帮助客户，且拥有独立的专业销售团队、技术支持团队、市场营销团队、进出口报关团队的高科技生物企业。可以为您提供及时的咨询响应，专业的产品和解决方案支持，稳健快捷的交货周期，优质放心的售后服务。我们致力于为您提供有价值的产品和服务，在意您的成功！
- 产品描述
- Myeloperoxidase (MPO: EC 1.11.2.2) is a peroxidase abundantly expressed in neutrophil granulocytes. It catalyzes the hydrogen peroxide dependent oxidation of halide ions to generate hypochlorite (HClO), the reaction by which MPO exhibits cytotoxic activity against tumor cells and microorganisms. MPO also oxidizes various substances such as phenol and anilines. MPO undergoes chlorination or peroxidation reaction depending upon the relative concentrations of chloride and the reducing substrates. Recent studies suggest that increased levels of MPO are associated with an increased risk for cardiovascular disease and myocardial infarction, thus development of novel and specific inhibitors of MPO is critical for therapeutic purposes.Intended Use:For use in screening, characterizing, and studying potential inhibitors of MPO.Test Principle:This MPO Inhibitor Screening BioAssay Kit provides screening assays for both MPO chlorination and peroxidation activities. In the chlorination assay (specific for MPO), MPO converts hydrogen peroxide and sodium chloride to sodium hypochlorite, which reacts with Chlorination substrate to give an intensely fluorescent product (Ex/Em= 480/520nm). In the Peroxidation Assay, MPO oxidizes peroxidation substrate to generate fluorescence (Ex/Em= 535/587nm). The fluorescence generated is directly proportional to any peroxidase activity present. In the presence of MPO inhibitor, reactions are impeded, thus decreasing the rate and/or extent of generation of MPO-dependent fluorescence. This kit provides a sensitive, quick, and easy method for screening potential inhibitors of MPO, and identifying whether one or both activities are inhibited. MPO Inhibitor Control is included to compare the efficacy of test inhibitors. The assay is high-throughput adaptable and can be performed in less than 20 min.Kit Components:MPO Assay Buffer, 1x50ml
MPO Chlorination Substrate, DMSO, 1x200ul
MPO Peroxidation Substrate, DMSO, 1x200ul
MPO Enzyme, lyophilized, 1x vial
Inhibitor Control (4-Aminobenzonic Hydrazide), DMSO, 1x100ul
Hydrogen Peroxide, 1x50ulStorage and Stability:Store powder at 4°C liquid at -20°C. Store other components at 4°C. Stable for at least 6 months For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- 产品特点
- 针对Myeloperoxidase (MPO) Inhibitor, Screening BioAssay Kit (Fluorometric)该产品的特点优势，欢迎查阅官网提供的产品说明书。
- 保存建议
- 建议收到Myeloperoxidase (MPO) Inhibitor, Screening BioAssay Kit (Fluorometric)产品后将其置于-20°C保存。
- 其他
- Usbiological公司是美国著名的抗体和生化试剂供应商，生产世界上种类最多的抗体，用于Western Blot、免疫沉淀、免疫荧光、免疫组化和流式细胞术等多种检测方法。Usbiological公司现已拥有超过50,19234种抗体、抗原和生化产品，为科研用户提供了诸多超值选择。
-
- 注意
-
该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
-
