Caspases are a family of cysteine proteases that play an essential role in carrying out apoptosis. Caspase-14，also named MICE，is a unique member of the caspase family with restricted expression； it is found in embryonic tissues and adult skin. Caspase-14 is weakly processed into p18 and p11 subunits by caspase-8. Caspase-14 may not play a role in apoptosis，but instead may regulate keratinocyte differentiation. Expression of caspase-14 may protect from psoriasis and irradiation damage. Caspase-14 may also be responsible for proteolytic processing of filaggrin during terminal differentiation of keratinocytes.
应用类型
Western blot （1:100）
免疫原
Synthetic peptide corresponding sequence surrounding amino acid 176 of human Caspase-14
