YK-4-279(25毫克)产品是YK-4-279 is an Inhibitor of RNA Helicase A (RHA) binding to the oncogenic transciption factor EWS-FLI1. At 10 uM, YK-4-279 blocks RHA binding to ES-FLI1 and induces apoptosis of a panel of Ewing’s sarcoma tumor cell lines with IC₅₀ values ranging from 0.5-2 uM. At 1.5 mg per dose, YK-4-279 reduces the growth of Ewing’s sarcoma orthotopic xenografts in mice after treatment with the inhibitor for two weeks.