中文名称

Foretinib

英文名字

Foretinib

供应商

USBiological

产品货号

276826

产品报价

￥1/5mg   ￥1/10mg   ￥1/25mg   ￥1/50mg   ￥1/100mg

产品说明书

点击查看

购买方式

银行转账、电汇、支票、现金，在线支付宝及网银支付，或直接与我们电话联系400-6800-868

产品新闻

背景资料

USBiological品牌是全球有名的抗原抗体和生化试剂供应商，生产世界上种类最多的抗体，用于Western Blot、免疫沉淀、免疫荧光、免疫组化和流式细胞术等多种检测方法。武汉艾美捷科技作为USBiological品牌中国区域总代理，是行业中少有的致力于服务客户，帮助客户，且拥有独立的专业销售团队、技术支持团队、市场营销团队、进出口报关团队的高科技生物企业。可以为您提供及时的咨询响应，专业的产品和解决方案支持，稳健快捷的交货周期，优质放心的售后服务。我们致力于为您提供有价值的产品和服务，在意您的成功！

产品描述

Foretinib, also known as EXEL-2880, XL880, and GSK1363089, is a small-molecule inhibitor of the hepatocyte growth factor (HGF) and vascular endothelial growth factor (VEGF) receptor tyrosine kinase families.Foretinib inhibited receptor tyrosine kinases (RTKs) in vitro with IC50 values of 0.4nM for Met and 3nM for Ron. It inhibited cellular Met with IC50 values of 23nM in PC-3 prostate cells and 21nM in murine B16F10 melanoma cells. It also reduced tumor cell migration, invasion, and endothelial tubule formation. Foretinib had cytotoxic activities against a broad panel of cell lines. It also blocked lung metastasis after the implantation of B16F10 solid tumors in mice.MET-amplified tumor lines with HER1 or HER2 amplification are more sensitive to the combination of foretinib with lapatinib or erlotinib. MET-overexpressing tumor cell lines with HER1 or HER2 amplification are less sensitive to lapatinib or erlotinib in the presence of HGF. Foretinib can reverse the effect of HGF on lapatinib or erlotinib sensitivity in these cells. Foretinib inhibits tumorigenesis and blocks invasive tumor growth in different models of ovarian cancer by affecting several critical tumor functions including inducing anoikis (anchorage-dependent programmed cell death) and inhibiting (1) c-Met activation and downstream signaling, (2) ovarian cancer cell adhesion, (3) migration and invasion, and (4) proliferation. Foretinib potently block multiple RTKs, including VEGF receptor and the receptor of HGF c-Met. Inhibition of c-Met and functionally related kinases intensifies the effects of VEGF receptor blockade, which leads to regression of tumor vasculature. Foretinib caused mitotic catastrophe in chronic myelogenous leukemia cells and other cell lines by JNK-dependent inhibition of Plk1 expression and induced apoptosis via a caspase 2-mediated mechanism. Foretinib had cytotoxic effects against gastric cancer cells harboring MET and FGFR2 amplification. It exerted its cytotoxic effects by blocking inter-RTK signaling networks with MET or FGFR2 at their center. Solubility:Soluble in DMSO at 150mg/mL; ethanol at 5mg/mL with warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 5-10uM; buffers, serum, or other additives may increase or decrease the aqueous solubility. Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 6 months at -20°C. Reconstitute with DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

产品形式

该产品为白色或类白色晶状固体。

保存建议

接收到Foretinib产品后，置于-20°C温度下保存。

其他

Usbiological公司是美国著名的抗体和生化试剂供应商，生产世界上种类最多的抗体，用于Western Blot、免疫沉淀、免疫荧光、免疫组化和流式细胞术等多种检测方法。Usbiological公司现已拥有超过50,19234种抗体、抗原和生化产品，为科研用户提供了诸多超值选择。

注意

该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。

分享到：