Necroptosis inhibitor. Blocks mixed lineage kinase domain-like protein (MLKL), a critical substrate of receptor-interacting serine-threonine kinase 3 (RIP3) during necrosis. Prevents MLKL-RIP1-RIP3 necrosome complex from interacting with downstream necrosis effectors.Synonyms:(2E)-N-[4-[[(3-Methoxy-2-pyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-2-propenamideCAS Number:1360614-48-7Molecular Formula:C₁₈H₁₅N₅O₆S₂.1⁄2H2OMolecular Weight:470.48Purity:≥98% (HPLC)Appearance:Supplied as a yellow solidSolubility:DMSO to 20mMMethod for Determining Identity:Proton NMR Spectroscopic and Mass Spectrometric AnalysisElemental Analysis:Calculated: %C: 45.95, %H: 3.43, %N: 14.89Storage and Stability:May be stored at 4°C. Light sensitive. Store in amber vial. Stable for 6 months after receipt.Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.
