Selective inhibitor of TGF-B type-I receptor (TGF-B RI, TGFR-I, TBR-I, ALK-5) (IC50 values are 59, 400 and 1400nM for TGR-B RI, TGF-B RII and MLK-7K respectively). Inhibits TGF-B-dependent luciferase production in mink lung cells (p3TP lux) and growth in mouse fibroblasts (NIH 3T3) (IC50 values are 47 and 89nM respectively). Suppresses invasion of MDA-MB-231 breast cancer cells in a matrigel invasion assay.Purity:≥99%Solubility:Soluble to 100mM in DMSOStorage:Store at RT