Potent and selective Iks channel blocker (IC50 values are 10.5 and 34nM in canine and guinea pig ventricular myocytes respectively). Selectively inhibits IKs currents over IKr, IKI, Ito and L-type Ca2+ channel currents. Also has little or no effect on Kv11.1 Kv1.5, Kv1.3, Kir2.1 and HCN2 channel currents. Potentiates E-4031-induced arrhythmias in vivo.Appearance:White solidPurity:≥99%Solubility:Soluble to 10mM in DMSO, 20mM in ethanolTLC:Rf = 0.06 (30% EtOAc in petroleum spiritsHPLC:≥99.4%Chiral HPLC:100%%1H NMR:Consistent with structureMass Spectrum:Consistent with structureMicroanalysis:Carbon Hydrogen Nitrogen Theoretical 49.63 5.88 3.4Found 49.81 5.98 3.45Storage:Store at RTCAS No:223749-46-0Molecular Weight:411.44Formula:C17H24F3NO5S
