Positive allosteric modulator of nicotinic a4B2 receptors; selectively increases the ionic current through a4B2 in the presence of ACh. Displays 14.7-fold selectivity for a4B2 over homomeric (a7) receptors. Moderately cytotoxic in HCT-116 cells. Also inhibits human muscle (aBε) and Torpedo (aBy) nAChRs (IC50 values are 1.0 and 0.1 μM, respectively) by binding in the ion channel.Synonyms:6-Bromo-2-(1,1-dimethyl-2-propenyl)-N-1H-indole-3-ethanamine hydrochlorideCAS Number:951322-11-5Molecular Formula:C16H21BrN2.HClMolecular Weight:357.72AppearanceWhite to off-white solidPurity:≥98% (HPLC)Solubility:DMSO35.77mg/ml (100mM)Water3.58mg/ml (10mM) with gentle warmingStorage4°C. Hygroscopic. Keep tightly closed and desiccated. Light sensitive.
