Eplerenone is a potassium-sparing diuretic that selectively blocks aldosterone activation of the mineralcorticoid receptor (IC50=122 nM), demonstrating little activity towards other steroid receptors (IC50 > 9uM for glucocorticoid, androgen, progesterone, and estrogen receptors). Aldosterone antagonists such as this compound have been indicated for the treatment of hypertension and heart failure.Melting Point: 225-245°CStorage and Stability:May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
