Antibiotic. Potent anticancer compound. Cell permeable, potent, selective and irreversible 20S proteasome inhibitor. Predominantly inhibits the chymotrypsin-like (CTRL) activity of the proteasome. Exhibits lower level inhibition of proteasome trypsin-like and caspase-like activitives (100 and 1,000-fold slower rates respectively). Anti-inflammatory. Antimicrobial and antimalarial. Anti-parasitic. Stimulates bone formation by inhibiting osteoblast proteasome activity. Induces Parkinson's-like symptoms in rats. The ubiquitin-proteasome system (UPS) and autophagy serve as two complementary, reciprocally regulated protein degradation systems. Blockade of UPS by Epoxomicin activates autophagy.Appearance:Supplied as a white to off-white solid.Purity:≥97% (NMR)Molecular Formula:C28H50N4O7Molecular Weight:554.7Solubility:Soluble in DMSO. Insoluble in water.Storage and Stability:Stable for at least 1 year after receipt when stored at -20°C.
产品形式
该产品为白色或类白色固体。
保存建议
接收到Epoxomicin (Antibiotic BU 4061T)产品后，置于-20°C温度下保存。
