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中文名称

N-己酰基生物素-D-赤型二氢鞘氨醇

英文名字
N-Hexanoyl-biotin-D-erythro-dihydrosphingosine
供应商
Matreya
产品货号
2212-5
产品报价
¥询价/5mg
产品说明书
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购买方式
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产品新闻
背景资料
This dihydroceramide analogue contains a biotin unit attached to the amine of the dihydrosphingosine moiety via a hexanoic acid linker and is ideal for use in sphingolipid studies. The biotin structure allows for attachment of the ceramide to streptavidin and avidin making it extremely useful for binding to substrates and for toxin detection1. Dihydroceramide is a critical intermediate in the de novo synthesis of ceramide, leading to many complex sphingolipids. It is synthesized by the acylation of sphinganine and is subsequently converted to ceramide via the enzyme dihydroceramide desaturase or into phytosphingosine via the enzyme C4-hydroxylase.2 Inhibition of ceramide synthase by some fungal toxins (such as fumonisin B1) causes an accumulation of dihydrosphingosine and sphinganine-1-phosphate and a decrease in dihydroceramide and other dihydrosphingolipids, leading to a number of diseases including oesophageal cancer.3 The dihydroceramide desaturase inhibitor N-(4-Hydroxyphenyl)-retinamide (4-HPR) has been tested as an anti-cancer agent; It inhibits the dihydroceramide desaturase enzyme in cells, resulting in a high concentration of dihydroceramide and dihydro-sphingolipids and this is thought to be the cause of its anti-cancer effects.4 Oxidative stress in cells causes an increase in the amount of dihydroceramide by potently inhibiting the desaturase enzyme.5 Dihydroceramide inhibits the formation of channels by ceramides and may thus reduce ceramide induced apoptosis in cells.6 While ceramide is well known for promoting apoptosis, dihydroceramide has long been considered to be inactive. However, there has recently been evidence that an accumulation of dihydroceramide can induce cell cycle arrest.7
产品描述
N-C6:0-Biotin-dihydroceramide|N-C6:0-Biotin-sphinganine
产品形式
该N-己酰基生物素-D-赤型二氢鞘氨醇产品为固体形式
保存建议
对于本产品,我们推荐使用-20℃蓝冰低温进行运输。在您收到货物后,我们建议在-20℃温度下冷冻保存,溶解使用说明请参考本品说明书。
其他
Matreya LLC是一家脂质生化公司,致力于开发和制造高质量的脂质和生物化学品。Matreya在化学合成以及天然产物提取和纯化方面经验丰富,生产出的产品具有最佳纯度。 Matreya产品线包括一系列鞘脂、糖脂、鞘糖脂、脂肪酸和酯、甾醇和维生素E异构体(生育酚和生育三烯酚)。专长是生产高纯度鞘氨醇、神经酰胺、硫酸酯、神经节苷脂、酶抑制剂、生育酚和生育三烯酚。是全球提供脂质产品最全的供应商之一。产品涉及生物化学、制药、微生物学、食品和农业等研究领域。
注意
该页面的中文产品信息的翻译,仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前,请浏览说明书确认。
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