RubR1 Activator, GF-15 (2'-Benzyloxy-2'-demethoxygriseofulvin, (2S,6'R)-(7-Chloro-4,6-dimethoxy-benzofuran-3-on)-2-spiro-1'-(2'-benzyloxy-6'-methylcyclohex-2'-en-4'-one), (2S,5'R)-3'-benzylo-RubR1 Activator, GF-15 (2'-Benzyloxy-2'-demethoxygriseofulvin, (2S,6'R)-(7-Chloro-4,6-dimethoxy-benzofuran-3-on)-2-spiro-1'-(2'-benzyloxy-6'-methylcyclohex-2'-en-4'-one), (2S,5'R)-3'-benzyloxy-7-chloro-4,6-dimethoxy-5'-methyl-spiro(benzofuran-2,4'-cy代理/参数/厂家-生化试剂-艾美捷科技有限公司

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中文名称: RubR1 Activator, GF-15 (2'-Benzyloxy-2'-demethoxygriseofulvin, (2S,6'R)-(7-Chloro-4,6-dimethoxy-benzofuran-3-on)-2-spiro-1'-(2'-benzyloxy-6'-methylcyclohex-2'-en-4'-one), (2S,5'R)-3'-benzylo

英文名字: RubR1 Activator, GF-15 (2'-Benzyloxy-2'-demethoxygriseofulvin, (2S,6'R)-(7-Chloro-4,6-dimethoxy-benzofuran-3-on)-2-spiro-1'-(2'-benzyloxy-6'-methylcyclohex-2'-en-4'-one), (2S,5'R)-3'-benzyloxy-7-chloro-4,6-dimethoxy-5'-methyl-spiro(benzofuran-2,4'-cy

背景资料: USBiological品牌是全球有名的抗原抗体和生化试剂供应商，生产世界上种类最多的抗体，用于Western Blot、免疫沉淀、免疫荧光、免疫组化和流式细胞术等多种检测方法。武汉艾美捷科技作为USBiological品牌中国区域总代理，是行业中少有的致力于服务客户，帮助客户，且拥有独立的专业销售团队、技术支持团队、市场营销团队、进出口报关团队的高科技生物企业。可以为您提供及时的咨询响应，专业的产品和解决方案支持，稳健快捷的交货周期，优质放心的售后服务。我们致力于为您提供有价值的产品和服务，在意您的成功！

产品描述: A cell-permeable 2'-benzyloxy griseofulvin derivative that displays enhanced mammalian cancer-selective toxicity (IC50 ≤2, ≤4, ≤12, and ≥30uM against panels of leukemia, myeloma, solid tumors, and non-malignant cell lines, respectively), but little antifungal activity, by activating spindle-assembly-checkpoint without affecting microtubule kinetochore attachment. Cancer cells are reported to undergo multipolar (MP) mitosis with normal or supernumerary centrosomes in the presence of GF-15, resulting in subsequent apoptotic cell death. Shown to retard HT29 colon cancer & OPM2 myeloma tumor expansion in mice (20mg/kg/day i.p.) in vivo. GF-15 half-life is expected to be least 48h in cultures.Solubility:DMSOMolar Mass:428.9Storage and Stability:May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.

保存建议: 接收到RubR1 Activator, GF-15 (2'-Benzyloxy-2'-demethoxygriseofulvin, (2S,6'R)-(7-Chloro-4,6-dimethoxy-benzofuran-3-on)-2-spiro-1'-(2'-benzyloxy-6'-methylcyclohex-2'-en-4'-one), (2S,5'R)-3'-benzyloxy-7-chloro-4,6-dimethoxy-5'-methyl-spiro(benzofuran-2,4'-cyclohex-2-ene)-1',3-dione, (1'S,6'R)-2'-(benzyloxy)-7-chloro-4,6-dimethoxy-6'-methyl-3H-spiro(benzofuran-2,1'-cyclohex[2]ene)-3,4'-dione, Supernumerary Centrosomes Clustering Inhibitor)产品后，置于4°C温度下保存。

其他: Usbiological公司是美国著名的抗体和生化试剂供应商，生产世界上种类最多的抗体，用于Western Blot、免疫沉淀、免疫荧光、免疫组化和流式细胞术等多种检测方法。Usbiological公司现已拥有超过50,19234种抗体、抗原和生化产品，为科研用户提供了诸多超值选择。