A cell-permeable, selective inhibitor of cAMP-specific phosphodiesterase (PDE IV; IC50=800nM). A rolipram-insensitive PDE IV subtype is also known to exist. Also inhibits NF-kB and NFAT activation in Jurkat and primary T cells.Formula:C16H21NO3Primary Target:PDE IVPrimary Target IC50:800nMSecondary Target:NF-kB and NFAT activation in Jurkat and primary T cellsSolubility:DMSOMolecular Weight:275.4Storage and Stability:May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.