- 中文名称
RAGE Antagonist, FPS-ZM1 (N-Benzyl-4-chloro-N-cyclohexylbenzamide, Receptor for AGE Antagonist, FPS-ZM1)
- 英文名字
- RAGE Antagonist, FPS-ZM1 (N-Benzyl-4-chloro-N-cyclohexylbenzamide, Receptor for AGE Antagonist, FPS-ZM1)
- 供应商
- USBiological
- 产品货号
- 217736
- 产品报价
- ￥1/25mg
- 产品说明书
- 点击查看
- 购买方式
- 银行转账、电汇、支票、现金，在线支付宝及网银支付，或直接与我们电话联系400-6800-868
- 产品新闻
- 背景资料
- USBiological品牌是全球有名的抗原抗体和生化试剂供应商，生产世界上种类最多的抗体，用于Western Blot、免疫沉淀、免疫荧光、免疫组化和流式细胞术等多种检测方法。武汉艾美捷科技作为USBiological品牌中国区域总代理，是行业中少有的致力于服务客户，帮助客户，且拥有独立的专业销售团队、技术支持团队、市场营销团队、进出口报关团队的高科技生物企业。可以为您提供及时的咨询响应，专业的产品和解决方案支持，稳健快捷的交货周期，优质放心的售后服务。我们致力于为您提供有价值的产品和服务，在意您的成功！
- 产品描述
- A blood-brain-barrier-permeant, non-toxic, tertiary amide compound that acts as a high affinity, potent, multimodal blocker of RAGE (Receptor for Advanced Glycation End products) V domain-mediated ligand binding (Ki = 25, 148, and 230nM, respectively, against Ab40, HMGB1, and S100B, binding to sRAGE). Blocks RAGE-mediated influx of Ab40 and Ab42 into the brain. Also shown to suppress Ab-RAGE induced NF-kB activation and NF-kB-dependent transcription of b-secretase. Daily treatment of APPsw/0 murine AD model (1mg/kg/d via i.p.) is reported to greatly reduce Thioflavin S-positive amyloid plaques in cortex and hippocampus (by 70 to 80%) and restore congnitive performance to the level of non-AD mice.Formula:C20H22ClNOMolecular Weight:327.9Solubility:DMSO (100mg/ml)Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile buffer or dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
- 产品形式
- 该产品为黄白色固体。
- 保存建议
- 接收到RAGE Antagonist, FPS-ZM1 (N-Benzyl-4-chloro-N-cyclohexylbenzamide, Receptor for AGE Antagonist, FPS-ZM1)产品后，置于-20°C温度下保存。
- 其他
- Usbiological公司是美国著名的抗体和生化试剂供应商，生产世界上种类最多的抗体，用于Western Blot、免疫沉淀、免疫荧光、免疫组化和流式细胞术等多种检测方法。Usbiological公司现已拥有超过50,19234种抗体、抗原和生化产品，为科研用户提供了诸多超值选择。
- 注意
-
该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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