PIP3 Antagonist II, DM-PIT-1, N-((2-Hydroxy-5-nitrophenyl)carbamothioyl)-3,5-dimethylbenzamide, N-(((2-Hydroxy-5-nitrophenyl)amino)thioxomethyl)-3,5-dimethyl-benzamide, Akt Inhibitor XXII, PDK1 Inhibi-PIP3 Antagonist II, DM-PIT-1, N-((2-Hydroxy-5-nitrophenyl)carbamothioyl)-3,5-dimethylbenzamide, N-(((2-Hydroxy-5-nitrophenyl)amino)thioxomethyl)-3,5-dimethyl-benzamide, Akt Inhibitor XXII, PDK1 Inhibitor VI)代理/参数/厂家-生化试剂-艾美捷科技有限公司

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中文名称: PIP3 Antagonist II, DM-PIT-1, N-((2-Hydroxy-5-nitrophenyl)carbamothioyl)-3,5-dimethylbenzamide, N-(((2-Hydroxy-5-nitrophenyl)amino)thioxomethyl)-3,5-dimethyl-benzamide, Akt Inhibitor XXII, PDK1 Inhibi

英文名字: PIP3 Antagonist II, DM-PIT-1, N-((2-Hydroxy-5-nitrophenyl)carbamothioyl)-3,5-dimethylbenzamide, N-(((2-Hydroxy-5-nitrophenyl)amino)thioxomethyl)-3,5-dimethyl-benzamide, Akt Inhibitor XXII, PDK1 Inhibitor VI)

背景资料: USBiological品牌是全球有名的抗原抗体和生化试剂供应商，生产世界上种类最多的抗体，用于Western Blot、免疫沉淀、免疫荧光、免疫组化和流式细胞术等多种检测方法。武汉艾美捷科技作为USBiological品牌中国区域总代理，是行业中少有的致力于服务客户，帮助客户，且拥有独立的专业销售团队、技术支持团队、市场营销团队、进出口报关团队的高科技生物企业。可以为您提供及时的咨询响应，专业的产品和解决方案支持，稳健快捷的交货周期，优质放心的售后服务。我们致力于为您提供有价值的产品和服务，在意您的成功！

产品描述: A cell-permeable benzoylthiourea compound that is shown to compete against PIP3 for binding PH domains of Akt1 (IC50 >31uM), ARNO, GRP1, and P1. Effectively blocks PIP3-dependent cellular PI3K-PDK1-Akt signaling pathway activation in U87MG (25 to 100uM for 3d) and PDGF-induced Akt and GRP membrane translocation in serum-starved SUM159 cells (1h 100uM pretreatment), while being inactive against PDGF-induced Btk translocation or PMA-induced PLC-delta and TAPP1/2 translocations. Although DM-PIT-1 can be administered as a DMSO stock for effective culture treatments, incorporating DM-PIT-1 into PEG-PE mixed micelles enhances its solubility (up to 1mM) and i.v. dosing limit for more effective in vivo administrations (5% vs. 41% of control 4T1 tumor size in mice via 1mg/kg micelles-formulated or 0.4mg/kg free drug daily i.v., respectively).Formula:C16H15N3O4SMolecular Weight:345.4Solubility:DMSO (25mg/ml)Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

保存建议: 接收到PIP3 Antagonist II, DM-PIT-1, N-((2-Hydroxy-5-nitrophenyl)carbamothioyl)-3,5-dimethylbenzamide, N-(((2-Hydroxy-5-nitrophenyl)amino)thioxomethyl)-3,5-dimethyl-benzamide, Akt Inhibitor XXII, PDK1 Inhibitor VI)产品后，置于-20°C温度下保存。

其他: Usbiological公司是美国著名的抗体和生化试剂供应商，生产世界上种类最多的抗体，用于Western Blot、免疫沉淀、免疫荧光、免疫组化和流式细胞术等多种检测方法。Usbiological公司现已拥有超过50,19234种抗体、抗原和生化产品，为科研用户提供了诸多超值选择。