- 中文名称
NF-kB Activation Inhibitor VIII, A-UBI (NEMO Ubiquitin Binding Domain Inhibitor)
- 英文名字
- NF-kB Activation Inhibitor VIII, A-UBI (NEMO Ubiquitin Binding Domain Inhibitor)
- 供应商
- USBiological
- 产品货号
- 217587
- 产品报价
- ￥1/2mg
- 产品说明书
- 点击查看
- 购买方式
- 银行转账、电汇、支票、现金，在线支付宝及网银支付，或直接与我们电话联系400-6800-868
- 产品新闻
- 背景资料
- USBiological品牌是全球有名的抗原抗体和生化试剂供应商，生产世界上种类最多的抗体，用于Western Blot、免疫沉淀、免疫荧光、免疫组化和流式细胞术等多种检测方法。武汉艾美捷科技作为USBiological品牌中国区域总代理，是行业中少有的致力于服务客户，帮助客户，且拥有独立的专业销售团队、技术支持团队、市场营销团队、进出口报关团队的高科技生物企业。可以为您提供及时的咨询响应，专业的产品和解决方案支持，稳健快捷的交货周期，优质放心的售后服务。我们致力于为您提供有价值的产品和服务，在意您的成功！
- 产品描述
- A cell-permeable 37-mer peptide derived from the NEMO NOA ubiquitin binding site (294-314 of mouse sequence with D304R), and fused with an Antennapedia cell penetrating protein (A) at the N-terminus. It is shown to attenuate NF-kB activation via blocking interactions between K63-polyubiquitin chains and the NOA ubiquitin binding domain of NEMO (=17uM for CC2-LZ/A-UBI complex). The biotin-labled A-UBI specifically inhibits the LPS-induced NF-kB activation (IC50=1.1uM, compared with 23uM for IKKb derived A-NBD) and TNF-a induced NF-kB activation (IC50=21uM) in 70Z/3-C3 pre-B lymphocytes. It displays an inhibitory effect on nuclear translocation of NF-kB p65 and IKK kinase activity at 10uM, but does not significantly affect other signaling pathways such as MAPK/ERK, MAPK/JNK, NF-kB and NFAT.Formula:C215H347N71O50S1 plus TFA and H2OSequence:RQIKIWFQNRRMKWKKLKAQADIYKARFQAERHAREKMolecular Weight:4758.6Solubility:H2O (50mg/ml)Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile buffer or dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
- 产品形式
- 该产品为白色粉末。
- 保存建议
- 接收到NF-kB Activation Inhibitor VIII, A-UBI (NEMO Ubiquitin Binding Domain Inhibitor)产品后，置于-20°C温度下保存。
- 其他
- Usbiological公司是美国著名的抗体和生化试剂供应商，生产世界上种类最多的抗体，用于Western Blot、免疫沉淀、免疫荧光、免疫组化和流式细胞术等多种检测方法。Usbiological公司现已拥有超过50,19234种抗体、抗原和生化产品，为科研用户提供了诸多超值选择。
- 注意
-
该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
-
