中文名称

Iron Chelator IV, 21H7 (6-Bromo-N’-(2-hydroxybenzylidene)-2-methylquinoline-4-carbohydrazide)

英文名字

Iron Chelator IV, 21H7 (6-Bromo-N’-(2-hydroxybenzylidene)-2-methylquinoline-4-carbohydrazide)

供应商

USBiological

产品货号

217467

产品报价

￥1/10mg

产品说明书

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购买方式

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产品新闻

背景资料

USBiological品牌是全球有名的抗原抗体和生化试剂供应商，生产世界上种类最多的抗体，用于Western Blot、免疫沉淀、免疫荧光、免疫组化和流式细胞术等多种检测方法。武汉艾美捷科技作为USBiological品牌中国区域总代理，是行业中少有的致力于服务客户，帮助客户，且拥有独立的专业销售团队、技术支持团队、市场营销团队、进出口报关团队的高科技生物企业。可以为您提供及时的咨询响应，专业的产品和解决方案支持，稳健快捷的交货周期，优质放心的售后服务。我们致力于为您提供有价值的产品和服务，在意您的成功！

产品描述

A cell-permeable salicylaldehyde-acylhydrazone iron chelator that is 20-times more efficient than DFO/desferrioxamine in depleting intracellular iron in colon cancer SW480 cells. Iron chelators exert their biological activities by affecting iron-regulated enzymes and singaling events, including HIF1a transcription activation due to inhibition of PHD- (prolyl hydroxylase) mediated HIF1a degradation, as well as altered mRNA translations due to enhanced IRP (Iron Regulatory Protein) IREs (Iron Response Elements) binding. Cellular iron depletion is also reported to inhibit the growths of colorectal adenocarcinoma cultures, DLD-1 (IC50=0.6 and 2.9uM, respectively, by 21H7 and DFO) and SW480 (IC50=1.0 and 3.8uM, respectively, by 21H7 and DFO), as a result of Wnt signaling pathway blockage (Effective conc.=5uM 21H7 or 100uM DFO).Formula:C18H14BrN3O2Molecular Weight:384.2Solubility:DMSO (5mg/ml light yellow solution)Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile buffer or dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

产品形式

该产品为类白色固体。

保存建议

接收到Iron Chelator IV, 21H7 (6-Bromo-N’-(2-hydroxybenzylidene)-2-methylquinoline-4-carbohydrazide)产品后，置于-20°C温度下保存。

其他

Usbiological公司是美国著名的抗体和生化试剂供应商，生产世界上种类最多的抗体，用于Western Blot、免疫沉淀、免疫荧光、免疫组化和流式细胞术等多种检测方法。Usbiological公司现已拥有超过50,19234种抗体、抗原和生化产品，为科研用户提供了诸多超值选择。

注意

该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。

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