Histone Acetyl Transferase Inhibitor VII, CTK7A (HBC, Na 4-(3,5-bis-(2-(4-Hydroxy-3-methoxy-phenyl)-ethyl)-4,5-dihydro-pyrazol-1-yl)-benzoic Acid, Na Salt Hydroxy-methoxy-phenyl-ethyl-dihydro-pyrazoly-Histone Acetyl Transferase Inhibitor VII, CTK7A (HBC, Na 4-(3,5-bis-(2-(4-Hydroxy-3-methoxy-phenyl)-ethyl)-4,5-dihydro-pyrazol-1-yl)-benzoic Acid, Na Salt Hydroxy-methoxy-phenyl-ethyl-dihydro-pyrazolyl-benzoic acid, Na Salt Sodium-4-(3,5-bis(4-hydrox代理/参数/厂家-生化试剂-艾美捷科技有限公司

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中文名称: Histone Acetyl Transferase Inhibitor VII, CTK7A (HBC, Na 4-(3,5-bis-(2-(4-Hydroxy-3-methoxy-phenyl)-ethyl)-4,5-dihydro-pyrazol-1-yl)-benzoic Acid, Na Salt Hydroxy-methoxy-phenyl-ethyl-dihydro-pyrazoly

英文名字: Histone Acetyl Transferase Inhibitor VII, CTK7A (HBC, Na 4-(3,5-bis-(2-(4-Hydroxy-3-methoxy-phenyl)-ethyl)-4,5-dihydro-pyrazol-1-yl)-benzoic Acid, Na Salt Hydroxy-methoxy-phenyl-ethyl-dihydro-pyrazolyl-benzoic acid, Na Salt Sodium-4-(3,5-bis(4-hydrox

背景资料: USBiological品牌是全球有名的抗原抗体和生化试剂供应商，生产世界上种类最多的抗体，用于Western Blot、免疫沉淀、免疫荧光、免疫组化和流式细胞术等多种检测方法。武汉艾美捷科技作为USBiological品牌中国区域总代理，是行业中少有的致力于服务客户，帮助客户，且拥有独立的专业销售团队、技术支持团队、市场营销团队、进出口报关团队的高科技生物企业。可以为您提供及时的咨询响应，专业的产品和解决方案支持，稳健快捷的交货周期，优质放心的售后服务。我们致力于为您提供有价值的产品和服务，在意您的成功！

产品描述: A cell-permeable and water soluble hydrazinobenzoylcurcumin (HBC) compound that acts as a selective, reversible and mixed mode inhibitor of p300/CBP and PCAF histone acetyltransferases (IC50<25 and 50uM, respectively) with minimal activity towards other histone modifying enzymes like, G9a, CARM1, HDAC1, SIRT2 and TIP60 (IC50>100uM). Blocks the autoacetylation of p300 and PCAF and histone acetylation, downregulates cyclin E expression and induces senescence-like growth arrest at 100uM in KB cells. Further, suppresses tumor growth in xenograft oral tumor nude mouse model (100mg/kg, i.p., b.i.d.) and reduces H3K14 and H3K9 acetylation levels. Reported to potently inhibit bFGF-induced bovine aortic endothelial cells (BAECs) invasion and tube formation with an IC50 of 0.93uM and binds to Ca2+/calmodulin with high-affinity (=8.11uM) and antagonize its functions in HCT15 cells.Formula:C28H23N2NaO6Solubility:DMSOMolecular Weight:506.5Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

保存建议: 接收到Histone Acetyl Transferase Inhibitor VII, CTK7A (HBC, Na 4-(3,5-bis-(2-(4-Hydroxy-3-methoxy-phenyl)-ethyl)-4,5-dihydro-pyrazol-1-yl)-benzoic Acid, Na Salt Hydroxy-methoxy-phenyl-ethyl-dihydro-pyrazolyl-benzoic acid, Na Salt Sodium-4-(3,5-bis(4-hydroxy-3-methoxystyryl)-1H-pyrazol-1-yl)benzoate, HAT Inhibitor VII, p300/CBP Inhibitor V, PCAF Inhibitor III, )产品后，置于-20°C温度下保存。

其他: Usbiological公司是美国著名的抗体和生化试剂供应商，生产世界上种类最多的抗体，用于Western Blot、免疫沉淀、免疫荧光、免疫组化和流式细胞术等多种检测方法。Usbiological公司现已拥有超过50,19234种抗体、抗原和生化产品，为科研用户提供了诸多超值选择。