GSK-3 Inhibitor IX ((2’Z,3’E)-6-Bromoindirubin-3’-oxime)-GSK-3 Inhibitor IX ((2’Z,3’E)-6-Bromoindirubin-3’-oxime)代理/参数/厂家-生化试剂-艾美捷科技有限公司

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产品描述: A cell-permeable bis-indolo (indirubin) compound that acts as a highly potent, selective, reversible, and ATP-competitive inhibitor of GSK-3a/b (IC50=5nM). Its specificity has been tested against various Cdk's (IC50=83, 300, 320, and 10,000nM for Cdk5/p25, Cdk2/A, Cdk1/B, and Cdk4/D1, respectively) as well as many other commonly studied kinases (IC50≥10uM), including MAP kinases, PKA, PKC isoforms, PKG, CK, and IRTK. Inhibition of GSK by BIO has been shown to result in the activation of Wnt-signaling pathway and sustained pluripotency in human and murine ESCs (embryonic stem cells). Reported to maintain self-renewal in human and mouse embryonic stem cells. Also induces the differentiation of neonatal cardiomyocytes. A 10mM (500ug/140ul) solution of GSK-3 Inhibitor IX in DMSO is also available.Formula:C16H10BrN3O2Primary Target:GSK-3a/bPrimary Target IC50:5nMSecondary Target:IC50 = 83, 300, 320, and 10,000nM for Cdk5/p25, Cdk2/A, Cdk1/B, and Cdk4/D1, respectively.Solubility:DMSOMolecular Weight:356.2Storage and Stability:May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.

保存建议: 接收到GSK-3 Inhibitor IX ((2’Z,3’E)-6-Bromoindirubin-3’-oxime)产品后，置于4°C温度下保存。

其他: Usbiological公司是美国著名的抗体和生化试剂供应商，生产世界上种类最多的抗体，用于Western Blot、免疫沉淀、免疫荧光、免疫组化和流式细胞术等多种检测方法。Usbiological公司现已拥有超过50,19234种抗体、抗原和生化产品，为科研用户提供了诸多超值选择。