A selective antagonist for group II mGlu receptors (mGlu2 and mGlu3) with low potency (at least 2000- to 3000-fold less potent than LY341495 at mGlu2 receptors expressed in CHO cells). Negligible or no activity at the group III metabotropic and ionotropic glutamate receptors. Extensively used in studies of hippocampal neural plasticity and neurological disorders.Formula:C7H13NO4Solubility:Aqueous basic solutionsPrimary Target:mGlu2/3Primary Target Ki:42 ± 6 →M - 94 ± 3 →M.Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
