A cell permeable ureido-sulfonamide Carbonic Anhydrase (CA) inhibitor that is selective for human hCA IX and hCA XII (KiEnM and 4.5nM, respectively) against two other physiologically relevant hCA isoforms (KiP80nM and 9640nM for hCA I and hCA II, respectively). It elicits anti-tumor growth effects dose-dependently from 19 to 38mg/kg in a mouse tumor growth model implanted with MDA-MB-231 LM2-4Luc+ cells, and demonstrates metastasis inhibition in a mouse metastasis model injected with 4T1 cells.Formula:C13H12FN3O3SMolecular Weight:309.3Solubility:DMSO (50mg/ml)Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
产品形式
该产品为粉末。
保存建议
接收到Carbonic Anhydrase IX/XII Inhibitor II, U-104 (CAIX Inhibitor II)产品后，置于-20°C温度下保存。
