A selective alpha-2A-adrenoceptor antagonist (Ki = 1.7nM and 144.5nM at alpha-2A and alpha-2B-adrenergic receptors respectively). Has been used to study regulation of neurotransmitter release from sympathetic nerves and shown to increase hippocampal noradrenaline release following systemic administration.Formula:C13H17N3 • C4H4O4Solubility:H2OPrimary Target:→2A-adrenoceptorPrimary Target Ki:1.7nM and 144.5nM at →2A and →2B-adrenergic receptors respectivelyMolar Mass:331.37Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
