A cell-permeable, non-specific inhibitor of cAMP and cGMP phosphodiesterases (IC50=2-50uM). Also acts as an adenosine receptor antagonist. Reported to inhibit TNF-a expression in adipocyte precursor cells.Formula:C10H14N4O2Primary Target:cAMP and cGMP phosphodiesterasesPrimary Target IC50:2-50uMSecondary Target:TNF-a expression in adipocyte precursor cellsSolubility:DMSO (100mM), Ethanol (10mg/ml), Methanol (50mg/ml)Molecular Weight:222.2Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
