中文名称

Tetanus Toxin C-Fragment, Clostridium tetani (FITC)

英文名字

Tetanus Toxin C-Fragment, Clostridium tetani (FITC)

供应商

USBiological

产品货号

215966

产品报价

￥1/10ug

产品说明书

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购买方式

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产品新闻

背景资料

USBiological品牌是全球有名的抗原抗体和生化试剂供应商，生产世界上种类最多的抗体，用于Western Blot、免疫沉淀、免疫荧光、免疫组化和流式细胞术等多种检测方法。武汉艾美捷科技作为USBiological品牌中国区域总代理，是行业中少有的致力于服务客户，帮助客户，且拥有独立的专业销售团队、技术支持团队、市场营销团队、进出口报关团队的高科技生物企业。可以为您提供及时的咨询响应，专业的产品和解决方案支持，稳健快捷的交货周期，优质放心的售后服务。我们致力于为您提供有价值的产品和服务，在意您的成功！

产品描述

Tetanus toxin is a potent neurotoxin that is taken up by presynaptic terminals at the neuromuscular junction, travels retrogradely within motor neurons and is transported transsynaptically to spinal cord interneurons. Upon entering the motor neuron, tetanus toxin associates with lipid rafts, is incorporated into non-acidified vesicles, sorted in a Rab 5/7 dependent pathway and transported to the cell body. The toxin is trancytosed so that it enters upstream inhibitory neurons where it cleaves VAMP-2, inhibiting neurotransmitter release. Tetanus toxin inhibits neurotransmitter release with great potency and selectivity, cleaving a bond in vesicle-associated membrane protein-2 (VAMP-2) or synaptobrevin-2, thereby preventing the fusion of synaptic vesicles with the presynaptic membrane. Tetanus toxoid is currently used as a vaccine to produce immunity to tetanus, the disease caused by Clostridium tetani. Additionally, tetanus toxoid functions as a carrier of conjugated polysaccharides in the development of vaccines against encapsulated bacterial pathogens.Tetanus toxin C-fragment consists of the C-terminal portion of the heavy chain of tetanus toxin. Although it is non toxic, it retains the binding and internalization properties associated with intact tetanus toxin. These properties make C-fragment and its conjugates useful in tracing nerve fiber connections in the CNS. Source: Tetanus Toxin, C-fragment from enzyme digested Clostridium tetani toxinBinding Ratio:This lot contains 11.2ug of FITC bound/mg of C-fragment, assuming an extinction coefficient at 493nm of 85,200 M-1cm-' for FITC.Toxicity:The C-fragment comprises the binding portion of intact tetanus toxin and is considered to be nontoxic. However, since the lethal dose of tetanus toxin in humans is <2.5ng/kg, contamination of this product with <0.1% intact toxin could provide enough toxin to cause death in a nonvaccinated person. Use this product with the assumption that a small amount of contamination by intact tetanus toxin is present. Storage and Stability:Lyophilized powder is stable for 12 months after receipt at -20°C. Reconstitute with sterile ddH2O prior to use. To avoid repeated freezing and thawing, aliquot reconstituted stock solution and store at -20°C. Reconstituted product is stable at -20°C for 12 months. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: FITC conjugates are sensitive to light and should be kept in the dark. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

产品形式

该产品为冻干粉 in 0.01M sodium phosphate, pH 7.5，缓冲液为：100ul sterile ddH2O。Labeled with fluorescein isothiocyanate (FITC)。

保存建议

接收到Tetanus Toxin C-Fragment, Clostridium tetani (FITC)产品后，置于4°C Do Not Freeze温度下保存。

其他

Usbiological公司是美国著名的抗体和生化试剂供应商，生产世界上种类最多的抗体，用于Western Blot、免疫沉淀、免疫荧光、免疫组化和流式细胞术等多种检测方法。Usbiological公司现已拥有超过50,19234种抗体、抗原和生化产品，为科研用户提供了诸多超值选择。

注意

该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。

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