- 中文名称
Diphtheria Toxin
- 英文名字
- Diphtheria Toxin
- 供应商
- USBiological
- 产品货号
- 215936
- 产品报价
- ￥1/1mg
- 产品说明书
- 点击查看
- 购买方式
- 银行转账、电汇、支票、现金，在线支付宝及网银支付，或直接与我们电话联系400-6800-868
- 产品新闻
- 背景资料
- USBiological品牌是全球有名的抗原抗体和生化试剂供应商，生产世界上种类最多的抗体，用于Western Blot、免疫沉淀、免疫荧光、免疫组化和流式细胞术等多种检测方法。武汉艾美捷科技作为USBiological品牌中国区域总代理，是行业中少有的致力于服务客户，帮助客户，且拥有独立的专业销售团队、技术支持团队、市场营销团队、进出口报关团队的高科技生物企业。可以为您提供及时的咨询响应，专业的产品和解决方案支持，稳健快捷的交货周期，优质放心的售后服务。我们致力于为您提供有价值的产品和服务，在意您的成功！
- 产品描述
- Corynebacterium diphtheriae is a Gram-positive, bacterium which infects epithelial cells of the upper respiratory tract and produces diphtheria toxin. Diphtheria toxin is proteolytically cleaved forming a two part toxin, held together by a disulfide bridge. The amino-terminal carries the toxin’s enzymatic activity, capable of ADP-ribosylation and inactivation of translation elongation factor 2 (EF-2). The carboxy-terminal domain binds to specific host receptors, the heparin-binding EGF-like growth factor (HB-EGF) on human epithelial cells and translocates the catalytic domain into the cell. After binding to the cell receptor, the toxin is taken up by endocytosis, the pH of the endocytic vesicle drops and the translocation region of the toxin helps guide the catalytic domain into the host cytoplasm where it is released. Within the cytoplasm, the diphtheria toxin catalytic domain ADP ribosylates EF-2, terminating protein synthesis and causing the death of the cell. Diphtheria toxin is highly potent and as little as one catalytic domain is thought to cause cell death. In cell culture, diphtheria toxin inhibits protein synthesis and causes death in cells carrying the HB-EGF receptor. This toxin has been used to specifically eliminate receptor-expressing cells in transgenic mice. Source: Diphtheria Toxin from Corynebacterium diphtheriae Endotoxin: ~21.6EU/mg (Kinetic chromagenic LAL assay)Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 6 months. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- 产品形式
- 该产品为冻干粉 in 0.01M Tris, pH 7.5, 0.001M Na2 EDTA，缓冲液为：1ml sterile ddH2O。
- 保存建议
- 接收到Diphtheria Toxin产品后，置于-20°C温度下保存。
- 其他
- Usbiological公司是美国著名的抗体和生化试剂供应商，生产世界上种类最多的抗体，用于Western Blot、免疫沉淀、免疫荧光、免疫组化和流式细胞术等多种检测方法。Usbiological公司现已拥有超过50,19234种抗体、抗原和生化产品，为科研用户提供了诸多超值选择。
- 注意
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该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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