Potent, orally applicable PI3K y inhibitor. PI3Ky is required for for T-cell and B-cell as well as mast cell migration and degranulation. As such, these kinases are attractive targets for potential anti-infmamatory drugs. TASP-0415914 has shown excellent results in cell based assays. It is orally available and has performed will in murine in vivo models. PI3Ky IC(50) 29nm, AKT IC(50) 294nm.Solubility: DSMOStorage and Stability:May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. Aliquots are stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
