中文名称

Thyroglobulin, Porcine (Tg)

英文名字

Thyroglobulin, Porcine (Tg)

供应商

USBiological

产品货号

209234

产品报价

￥1/10mg

产品说明书

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购买方式

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产品新闻

背景资料

USBiological品牌是全球有名的抗原抗体和生化试剂供应商，生产世界上种类最多的抗体，用于Western Blot、免疫沉淀、免疫荧光、免疫组化和流式细胞术等多种检测方法。武汉艾美捷科技作为USBiological品牌中国区域总代理，是行业中少有的致力于服务客户，帮助客户，且拥有独立的专业销售团队、技术支持团队、市场营销团队、进出口报关团队的高科技生物企业。可以为您提供及时的咨询响应，专业的产品和解决方案支持，稳健快捷的交货周期，优质放心的售后服务。我们致力于为您提供有价值的产品和服务，在意您的成功！

产品描述

Thyroglobulin (Tg) is a 660kD, dimeric protein produced by and used entirely within the thyroid gland. In earlier literature, Tg was referred to as "colloid". Tg is used by the thyroid gland to produce the thyroid hormones thyroxine (T4) and triiodothyronine (T3). The active form of triiodothyronine, 3, 5, 3' triiodothyronine, is produced both within the thyroid gland and periphery by 5'-deiodinase (which has been referred to as tetraiodothyronine 5' deiodinase.)Thyroglobulin should not be confused with Thyroxine-binding globulin, a carrier protein responsible for carrying the thyroid hormones in the blood. Tg is produced by the thyroid epithelial cells, called thyrocytes, which form spherical follicles. Tg is secreted and stored in the follicular lumen Via a reaction with the enzyme thyroperoxidase, iodine is covalently bound to tyrosine residues in thyroglobulin molecules, forming monoiodotyrosine (MIT) and diiodotyrosine (DIT).Thyroxine is produced by combining two moieties of DIT. Triiodothyronine is produced by combining one molecule of MIT and one molecule of DIT. Proteases in lysosomes digest iodinated thyroglobulin, releasing T3 and T4. Patients with Hashimoto's thyroiditis or Graves' disease, frequently develop antibodies against Tg. Tg-specific antibodies help in the diagnosis of these diseases, but they also may be present in apparently healthy euthyroid individuals.Thyroglobulin levels in the blood can be used as a tumor marker for certain kinds of thyroid cancer. Thyroglobulin levels in the blood can also be elevated in cases of Graves' disease. Tg has large number of tyrosine residues and other amino acids (Lysine, glutamic and aspartic acid) for coupling.Source:Thyroglobulin, from porcine Thyroid glands.Molecular Weight:~660kD; subunit ~330kDApplications: Suitable for use as a carrier protein for conjugating small peptides, haptens or proteins to increase antigenicity, as an antigen for ELISA and Western Blot and for affinity column preparation to enrich or remove human anti-Tg antibodies from serum or plasma. Other applications not tested.Recommended Dilution:Optimal dilutions to be determined by the researcher.Storage and Stability:Lyophilized powder may be stored at -20°C. Reconstitute with sterile buffer. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

产品形式

该产品为冻干粉 in 0.02M NaHCO3。No preservative added，缓冲液为：sterile PBS, pH 7.0, 0.15M sodium chloride。

保存建议

接收到Thyroglobulin, Porcine (Tg)产品后，置于-20°C温度下保存。

其他

Usbiological公司是美国著名的抗体和生化试剂供应商，生产世界上种类最多的抗体，用于Western Blot、免疫沉淀、免疫荧光、免疫组化和流式细胞术等多种检测方法。Usbiological公司现已拥有超过50,19234种抗体、抗原和生化产品，为科研用户提供了诸多超值选择。

注意

该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。

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