中文名称

nRNP Complex, Calf Spleen

英文名字

nRNP Complex, Calf Spleen

供应商

USBiological

产品货号

208573

产品报价

￥1/1000U

产品说明书

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购买方式

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产品新闻

背景资料

USBiological品牌是全球有名的抗原抗体和生化试剂供应商，生产世界上种类最多的抗体，用于Western Blot、免疫沉淀、免疫荧光、免疫组化和流式细胞术等多种检测方法。武汉艾美捷科技作为USBiological品牌中国区域总代理，是行业中少有的致力于服务客户，帮助客户，且拥有独立的专业销售团队、技术支持团队、市场营销团队、进出口报关团队的高科技生物企业。可以为您提供及时的咨询响应，专业的产品和解决方案支持，稳健快捷的交货周期，优质放心的售后服务。我们致力于为您提供有价值的产品和服务，在意您的成功！

产品描述

nRNP Complex antigen is a non-histone nuclear protein composed of several polypeptides of differing molecular weights. It has been shown that RNP and Sm are distinct antigenic sites on the same nuclear molecular matrix consisting of RNA and eight polypeptides, including 70kD, A(33kD), C(22kD) and the Sm peptides B (26kD), B'(27kD), D(13 kD), E/F (11kD doublet), and G (9kD). Autoantibodies against the nRNP antigen precipitate the U1a and U1b small nuclear RNAs (2). The nRNP antigen is involved in normal post transcriptional, premessenger RNA processing to excise introns. (3) It has been demonstrated that the nRNP antigen is both RNase and tryptic digestion sensitive (4). Autoantibodies to the nRNP antigen, in high titers, have been strongly associated with patients who have Mixed Connective Tissue Disease (MCTD) (5). Other studies have shown that antibodies against the 70kD polypeptide are found more frequently in sera of MCTD than in anti-nRNP positive SLE patients (6). It has been suggested that patients showing anti-nRNP antibodies tend to have some of the clinical features of MCTD, regardless of their overall disease diagnosis (7). Anti-nRNP antibodies only bind the U1 RNP while the anti-Sm binds with the U1 RNP, U2RNP, U4/6RNP, AND U5RNP. Anti-RNP antibodies are often accompanied by anti-Sm antibodies (1). Double immunodiffusion was the original method for detecting anti-nRNP. Passive hemagglutination was popularized later (8). Source:nRNP Complex, purified from calf spleenUnit Definition:The amount of antigen that will generate an absorbance of 1.2 when assayed using standard procedure for enzyme immunoassay. Activity will vary with assay conditionsApplications:Recommended for use in standard solid phase immunoassays. Other applications not tested.Recommended Dilution:Optimal dilutions to be determined by the researcher.Storage and Stability:Aliquot to avoid repeated freezing and thawing and store at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

产品形式

该产品为液体形式，缓冲液为：01M Tris, 0.53M sodium chloride, 0.02% sodium azide。

保存建议

接收到nRNP Complex, Calf Spleen产品后，置于-70°C温度下保存。

其他

Usbiological公司是美国著名的抗体和生化试剂供应商，生产世界上种类最多的抗体，用于Western Blot、免疫沉淀、免疫荧光、免疫组化和流式细胞术等多种检测方法。Usbiological公司现已拥有超过50,19234种抗体、抗原和生化产品，为科研用户提供了诸多超值选择。

注意

该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。

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