Potent and selective cell permeable B-Raf (V600E) and c-Raf-1 (Y340D/Y341D) inhibitor. Antitumor compound. ERK phosphorylation is potently inhibited exclusive in B-Raf(V600E)-bearing tumor cell lines.Source:SyntheticFormula:C17H14ClF2N3O3S Solubility:DMSO or ethanolMolecular Weight:~413.8Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with DMSO or ethanol. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.