Immune response modifier. Antiviral and antitumor compound. Selective ligand for human or mouse Toll-like receptor 7 (TLR7). Induces the activation of NF-kappaB in HEK 293 cells expressing TLR7 at 0.1ug/ml. 10 times more active than Imiquimod. At high concentrations (3ug/ml) slightly activates TLR8. Shows adjuvant activity to increase the effectiveness of vaccines.Source:SyntheticFormula:C17H23N5OSolubility:DMSO, dioxane, methanol or acetonitrileMolecular Weight:~313.4Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
