Macrolide antibiotic. Specific vacuolar-type H+-ATPase inhibitor. Distinguishes among different types of ATPases. Inhibitor of endosomal, lysosomal and vacuolar acidification. Inhibitor of autophagic degradation by rising pH and thus inactivating the lysosomal acid hydrolases. Neuroprotective.Source:Streptomyces griseusFormula:C35H58O9 Solubility:DMSO, 100% ethanol or methanolMolecular Weight:~622.8Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
