Less toxic, more potent synthetic derivative of geldanamycin. Angiogenesis inhibitor. Heat shock protein 90 (HSP90) inhibitor. Apoptosis inducer. Shows higher antitumor activity than 17-AAG. Source:Semi-synthetic derivative from geldanamycinFormula:C32H48N4O8 Solubility:H2O, 100% ethanol (10mg/ml) or DMSO (~25mg/ml).Molecular Weight:~616.8Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
