Potent, less toxic analog of geldanamycin. Inhibits the essential ATPase activity of HSP90. Telomerase activity inhibitor. Apoptosis inducer. Antitumor compound.Source:Semi-synthetic derivative from geldanamycinFormula:C31H43N3O8 Solubility:DMSO (~10mg/ml) or methanol (~10mg/ml)Molecular Weight:~585.7Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
