ZM 447439(1毫克)产品是Cell-permeable. A selective, ATP-competitive inhibitor of Aurora B kinase in vitro (IC₅₀ values are 50 nM, 250 nM and 1 uM for Aurora B, C and A kinases respectively). Selective over a range of other kinases including cdk1 and PLK1 (IC₅₀ > 10 uM).