- 中文名称
12-oxo Leukotriene B4 (500 ug)
- 英文名字
- 12-keto LTB4|12-oxo LTB4, 12-oxo Leukotriene B4, 5S-hydroxy-12-oxo-6Z,8E,1E,14Z-eicosatetraenoic acid
- 供应商
- Cayman
- 产品货号
- 20140-500
- 产品报价
- ￥30016/500 ug
- 产品说明书
- 点击查看
- 购买方式
- 产品新闻
- 背景资料
- Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from arachidonic acid through the 5-LO pathway. It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis. 12-oxo LTB4 is an initial metabolite of LTB4 formed via the LTB4 12-hydroxydehydrogenase pathway. It is rapidly converted to 10,11-dihydro-12-oxo-LTB4, followed by reduction of the 12-oxo group to give 10,11-dihydro-LTB4. 12-oxo-LTB4 (EC50 = 33 nM) is about 70-fold less potent than LTB4 (EC50 = 0.46 nM) at stimulating Ca2+ mobilization in human neutrophils. It is also significantly less potent than LTB4 at stimulating neutrophil migration with EC50 values of 170 and 2.7 nM for 12-oxo-LTB4 and LTB4, respectively.
- 产品描述
- An initial metabolite of LTB4 with significantly reduced biological activity
- 产品形式
- 保存建议
- -80
- 其他
- Cayman Chemical
- 注意
-
该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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