Anti-Gremlin Antibody detects human Gremlin. In Xenopus, Gremlin belongs to a novel gene family that act as BMP antagonists in embryonic explants. The human homolog of Gremlin (CKTSF1B1) is localized on chromosome 15q13--> q15. DRM-specific mRNA is expressed in different tissues, including brain, ovary, intestine and colon. It has been suggested that down-regulation of Gremlin is associated with tumor progression, and support the hypothesis that Gremlin may play an important role during both neuroembryological development and carcinogenesis. Anti-Gremlin Antibody is ideal for investigators involved in NFkappaB, signaling, and cell cycle protein research.
应用类型
Immunohistochemistry,Western Blot,
免疫原
Gremlin Antibody was produced from whole rabbit serum prepared by repeated immunizations with a synthetic peptide corresponding to the internal amino acid sequences within the Gremlin-1 human protein.
来源宿主
Rabbit
反应性
H. sapiens (Human)
保存建议
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
