Anti-RANKL TRANCE CD254 detects mouse RANKL TRANCE CD254. RANKL, or Trance, is a member of tumor necrosis factor family. Trance (TNF-related activation-induced cytokine receptor) or RANKL {receptor activator of NF-kB (RANK) ligand} has been implicated in interactions between T cells and DCs. Trance binds to RANK on DCs and upregulates the expression of anti-apoptotic protein BcL-XL suggesting a role in DC survival. Trance is also important in T- and B-cell maturation. As OPGL/ODF (Osteoprotegerin Ligand/Osteoclast differentiation factor), the same protein can both activate mature osteoclasts and mediate osteoclastogenesis. Trance deficient mice show severe osteoporesis and complete absence of osteoclasts as a result of lack of osteogenesis. Anti-RANKL TRANCE CD254 is ideal for investigators involved in apoptosis research.
应用类型
Immunohistochemistry,Western Blot,
免疫原
RANKL Antibody was produced in mice by repeated immunizations with a bacterially expressed fusion protein corresponding to the n-terminus RANKL protein.
来源宿主
Mouse
反应性
H. sapiens (Human)
保存建议
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
