MDC1, mediator of DNA damage checkpoint protein 1, plays a role in checkpoint mediated cell cycle arrest in response to DNA damage, within S phase and G2/M. It is also thought to act as a scaffold protein during recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage that are marked by phosphorylation of histone H2A.X on S139.
应用类型
IF Microscopy,
免疫原
MDC1 Antibody was produced in mice by repeated immunizations with a recombinant protein corresponding to mouse MDC1 at and around the N-terminus region.
来源宿主
Mouse
反应性
Bovine (Bos Taurus); H. sapiens (Human); Mus musculus (Mouse); Pan troglodytes (Chimpanzee)
保存建议
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
