PCNA (proliferating cell nuclear antigen), which is the DNA polymerase delta auxiliary protein acting in homotrimeric form to increase the processivity of leading strand synthesis during DNA replication. PCNA is expressed in the nucleus of all proliferating cells. In response to DNA damage, it is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. PCNA is a useful marker of DNA synthesis, as its form not involved in DNA synthesis degradates in histological preparations in the presence of organic solvents.
应用类型
FC (QC tested)
免疫原
recombinant rat PCNA
来源宿主
小鼠
反应性
Mouse, Human, Non-human primates, Drosophila, Chicken, Rat
保存建议
Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. Do not use after expiration date stamped on vial label.
