A selective CRF1 antagonist (Ki = 4 nM); inhibits cAMP accumulation and ACTH production in vitro (pIC50s = 7.1 and 6.9, respectively) and reduces CRF- and stress-induced ACTH production in vivo
产品描述
A selective CRF1 antagonist (Ki = 4 nM); inhibits cAMP accumulation and ACTH production in vitro (pIC50s = 7.1 and 6.9, respectively) and reduces CRF- and stress-induced ACTH production in vivo