A selective IDO1 inhibitor (IC50 = 7-15 nM in cells) that promotes T and natural killer–cell growth, increases IFN-γ production, and reduces conversion to regulatory Treg–like cells in coculture systems of human allogeneic lymphocytes with dendritic cells or tumor cells; significantly inhibits tumor growth, in a lymphocyte-dependent manner, in mice bearing PAN02 pancreatic cancer cell xenografts
产品描述
A selective IDO1 inhibitor (IC50 = 7-15 nM in cells) that promotes T and natural killer–cell growth, increases IFN-γ production, and reduces conversion to regulatory Treg–like cells in coculture systems of human allogeneic lymphocytes with dendritic cells or tumor cells; significantly inhibits tumor growth, in a lymphocyte-dependent manner, in mice bearing PAN02 pancreatic cancer cell xenografts